New ethical considerations in vaccine trials

Ethical considerations in AIDS vaccine trials.

Ethical Considerations in Clinical Trials

Accessible online at: www.karger.com/journals/hed Ethical aspects of biomedical research in humans have been unmasked at a late stage in the history of science. They have been apparent for not more than approximately 60 years, and did not gain attention as a result of ongoing refinements of fundamental human rights. On the contrary, their recognition followed a traditional pattern in the histor...

Placebo-controlled trials of new drugs: ethical considerations.

Much controversy exists regarding the ethics of placebo-controlled trials in which an experimental therapy will compete with an already established treatment (or treatments). In such cases, argue critics, patients in the control arm of the study should receive an accepted therapy rather than a placebo. By using an active and effective drug, the control patients would not be placed at risk for d...

Ethical Considerations in HIV preventative vaccine research

Ethical issues in tuberculosis vaccine trials.

Bacille Calmette-Guérin (BCG) vaccines are widely used, even though estimates of efficacy have ranged from zero to 80%. BCG is a relatively safe vaccine, but it can cause disseminated infection, especially in immunocompromised hosts. Thus, the development of a more reliably efficacious and safer vaccine is important to the control of tuberculosis. The testing of any new vaccine in human populat...